Squamous cell carcinoma (SCC) of the eyelids is a neoplastic process, which more commonly affects white or minimally pigmented animals. UV sunlight may contribute to the development of these lesions, which progress from focal acanthosis through carcinoma-in-situ to outright squamous cell carcinoma with time. Carcinomas affecting the eyelid are more commonly encountered in feline patients and typically present as irregular, pink to red, erosive and/or proliferative lesions, which may be associated with local blepharoconjunctivitis, mucoid discharge and/or hemorrhage. Carcinomas are aggressive and locally invasive tumors, which may extend into surrounding tissues, including the conjunctiva, globe and orbit.