Primary, bullous retinal detachment represents a separation of the neurosensory retina from the underlying RPE due to sub-retinal fluid accumulation. This process is suspected to be immune-mediated in etiology. Clinical symptoms typically comprise bilaterally dilated poorly, or non-responsive pupils in association with acute onset blindness. Retinal tissue may be noted to be “billowing” forward posterior to level of the pupils. Funduscopically, complete or multiple areas of (non-hemorrhagic) bullous detachment are noted. Commonly affected breeds include the German Shepherd, Australian Shepherd and Labrador Retriever.