A corneal abscess may form following a breakdown in the epithelial (or rarely endothelial) barrier, allowing bacterial &/or fungal organisms entry into the corneal stroma, resulting in the formation of a nidus of infectious and/or inflammatory material. Clinically, this condition presents as a variably-sized, focal tan to yellow area of stromal corneal discoloration, which is typically associated with intense discomfort as well as an aggressive vascular response. Treatment includes the exposure and removal of the infective focus via debridement/curettage as well as the institution of aggressive systemic an/or topical anti-microbial therapy. Intact epithelial surfaces and/or significant accumulations of biologic material are significant impediments to antimicrobial penetration and healing.